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AJ Brown over 68.5 receiving yards
Brown was visibly frustrated with his role against Minnesota and I fully expect Philadelphia to get him more involved his week. Tampa Bay gave up 159 yards to Justin Jefferson in week 1 and 105 yards to DJ Brown in week 2. I think both WRs for Philly can go off, but I think there is an emphasis on getting Brown going.
Mark Andrews over 49.5 receiving yards
The Colts have been awful against the pass this year and Andrews looks like he is going to be the primary guy here, with a team-high 8 targets in his first game last week. The Colts gave up 110 yards to opposing TEs through 2 games and none of them have close to the talent that Andrews does. I think Andrews has a big day here.
Travis Etienne over 65.5 rushing yards
In a game that Jacksonville is expected to control, I think that Etienne will get a lot of volume. Etienne had 18 carries in a Week 1 blowout of the Colts and Houston has the worst run defense according to PFF Rush Defense grades. I think this is a nice spot for him to go off and have a ceiling-type game.
Alexander Mattison under 51.5 rushing yards
Minnesota has shown that it wants to throw the ball, with 97 passes to just 25 runs through 2 games. This is a game that should be high-scoring and both teams will have to air it out. Mattison has also not been very efficient, rushing for just 3.2 yards per carry on the year. This just screams under in this matchup.
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